Nikki Galrani is born as the youngest daughter of Manohar Galrani and Reshma at Bangalore. She has an elder sister, Sanjjanaa who is also an actress.In January 2013, Nikki signed her first film project. She was chosen to play the lead role in Ajith, the Kannada remake of the Tamil film Paiyaa, after an audition. Within three days, she had signed her next project, her first Tamil film, Yagavarayinum Naa Kaakka and few weeks later, her first Malayalam film as well: 1983. In spite of being the last film she signed in 2013, 1983 released first in early 2014 and became her debut film.